Schizophrenia CA2 Neuron 01-04-16 FINAL
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چکیده
NEW YORK—Scientists at Columbia University’s Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University Medical Center (CUMC), and the Université Paris Descartes have found that deficits in social memory—the inability to recognize familiar faces and a feature of psychiatric disorders such as schizophrenia—may be due to a decrease in the number of a particular class of brain cells, called inhibitory neurons, in a little-explored region within the brain’s memory center.
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Age-Dependent Specific Changes in Area CA2 of the Hippocampus and Social Memory Deficit in a Mouse Model of the 22q11.2 Deletion Syndrome
Several neuropsychiatric disorders are associated with cognitive and social dysfunction. Postmortem studies of patients with schizophrenia have revealed specific changes in area CA2, a long-overlooked region of the hippocampus recently found to be critical for social memory formation. To examine how area CA2 is altered in psychiatric illness, we used the Df(16)A(+/-) mouse model of the 22q11.2 ...
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تاریخ انتشار 2016